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Article

Regulation of feedback between protein kinase A and the proteasome system worsens Huntington's disease.

Molecular and cellular biology - 1 Mar 2013

Lin Jiun-Tsai, Chang Wei-Cheng, Chen Hui-Mei, Lai Hsing-Lin, Chen Chih-Yeh, Tao Mi-Hua, Chern Yijuang

Abstract excerpt

Huntington's disease (HD) is a neurodegenerative disease caused by the expansion of a CAG repeat in the Huntingtin (HTT) gene. Abnormal regulation of the cyclic AMP (cAMP)/protein kinase A (PKA) pathway occurs during HD progression. Here we found that lower PKA activity was associated with proteasome impairment in the striatum for two HD mouse models (R6/2 and N171-82Q) and in mutant HTT (mHTT)-expressing...

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Source

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Identifiers

PMID: 23275441
DOI: 10.1128/MCB.01434-12
PMCID: PMC3623082

Genes

HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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