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Article

The 'faulty male' hypothesis for sex-biased mutation and disease.

Current biology : CB - 20 Nov 2023

Hahn Matthew W, Peña-Garcia Yadira, Wang Richard J

Abstract excerpt

Biological differences between males and females lead to many differences in physiology, disease, and overall health. One of the most prominent disparities is in the number of germline mutations passed to offspring: human males transmit three times as many mutations as do females. While the classic explanation for this pattern invokes differences in post-puberty germline replication between the sexes, recent...

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Identifiers

PMID: 37989088
DOI: 10.1016/j.cub.2023.09.028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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