Article

Widespread transcriptional scanning in the testis modulates gene evolution rates

2018-03-14

Abstract excerpt

The testis expresses the largest number of genes of any mammalian organ, a finding that has long puzzled molecular biologists. Analyzing our single-cell transcriptomic maps of human and mouse spermatogenesis, we provide evidence that this widespread transcription serves to maintain DNA sequence integrity in the male germline by correcting DNA damage through 'transcriptional scanning'. Supporting this model, we fin...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f77c1026-6e0f-55d5-bca9-d92bb96139d3
DOI: 10.1101/282129

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Widespread transcriptional scanning in the testis modulates gene evolution ratesDOI 10.1101/282129Read

Gene expression levels modulate germline mutation rates through the compound effects of transcription-coupled repair and damage.Semantic proximity Read

Gene expression levels tune germline mutation rates through the compound effects of transcription-coupled repair and damageSemantic proximity Read

Comparative single cell analysis of transcriptional bursting reveals the role of genome organization on <i>de novo</i> transcript originationSemantic proximity Read

The conserved genetic program of male germ cells uncovers ancient regulators of human spermatogenesisSemantic proximity Read

Evolutionary innovations in germline biology of placental mammals revealed by transcriptomics of first wave spermatogenesis in opossumSemantic proximity Read

Widespread haploid-biased gene expression in mammalian spermatogenesis associated with frequent selective sweeps and evolutionary conflictSemantic proximity Read

Applications of single-cell RNA sequencing in spermatogenesis and molecular evolutionSemantic proximity Read

The adult human testis transcriptional cell atlasSemantic proximity Read

A single-cell multiomics roadmap of zebrafish spermatogenesis reveals regulatory principles of male germline formationSemantic proximity Read

Mutational bias in spermatogonia impacts the anatomy of regulatory sites in the human genomeSemantic proximity Read

Mutational bias in spermatogonia impacts the anatomy of regulatory sites in the human genome.Semantic proximity Read

Genomic signatures of germline gene expression.Semantic proximity Read