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Article

PPARG governs adipogenic differentiation and cell state plasticity in well-differentiated and dedifferentiated liposarcoma

2025-07-21

Abstract excerpt

Well-differentiated and dedifferentiated liposarcoma (WD/DD LPS) represent a pathological continuum, often coexisting within the same tumor. While the dedifferentiated component is clinically aggressive, marked by rapid growth and metastatic potential, the evolutionary relationship between WD and DD LPS remains unknown. To investigate this, we performed single-nucleus RNA sequencing on matched WD and DD tumor regi...

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Literature Corpus work
762efe35-68ac-5fe1-ad2f-c1da22918f80
DOI
10.1101/2025.07.16.665211
Open publication

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PPARG governs adipogenic differentiation and cell state plasticity in well-differentiated and dedifferentiated liposarcomaDOI 10.1101/2025.07.16.665211
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