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Article

Update on genomic and molecular landscapes of well-differentiated liposarcoma and dedifferentiated liposarcoma.

Molecular biology reports - 1 Apr 2021

Lu Jun, Wood David, Ingley Evan, Koks Sulev, Wong Daniel

Abstract excerpt

Well-differentiated liposarcoma (WDLPS) is the most frequent subtype of liposarcoma and may transform into dedifferentiated liposarcoma (DDLPS) which is a more aggressive subtype. Retroperitoneal lesions of WDLPS/DDLPS tend to recur repeatedly due to incomplete resections, and adjuvant chemotherapy and radiotherapy have little effect on patient survival. Consequently, identifying therapeutic targets and...

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PMID: 33893924
DOI: 10.1007/s11033-021-06362-5

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