Article
Genomic profiling of dedifferentiated liposarcoma compared to matched well-differentiated liposarcoma reveals higher genomic complexity and a common origin.
Cold Spring Harbor molecular case studies - 1 Apr 2018
Beird Hannah C, Wu Chia-Chin, Ingram Davis R, Wang Wei-Lien, Alimohamed Asrar, Gumbs Curtis, Little Latasha, Song Xingzhi, Feig Barry W, Roland Christina L, Zhang Jianhua, Benjamin Robert S, Hwu Patrick, Lazar Alexander J, Futreal P Andrew, Somaiah Neeta
Abstract excerpt
Well-differentiated (WD) liposarcoma is a low-grade mesenchymal tumor with features of mature adipocytes and high propensity for local recurrence. Often, WD patients present with or later progress to a higher-grade nonlipogenic form known as dedifferentiated (DD) liposarcoma. These DD tumors behave more aggressively and can metastasize. Both WD and DD liposarcomas harbor neochromosomes formed from amplifications...
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