Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Frequent alterations and epigenetic silencing of differentiation pathway genes in structurally rearranged liposarcomas.

Cancer discovery - 1 Dec 2011

Taylor Barry S, DeCarolis Penelope L, Angeles Christina V, Brenet Fabienne, Schultz Nikolaus, Antonescu Cristina R, Scandura Joseph M, Sander Chris, Viale Agnes J, Socci Nicholas D, Singer Samuel

Abstract excerpt

UNLABELLED: We explored diverse alterations contributing to liposarcomagenesis by sequencing the genome, exome, transcriptome, and cytosine methylome of a primary and recurrent dedifferentiated liposarcoma (DLPS) from distinct chemotherapy/radiotherapy-naïve patients. The liposarcoma genomes had...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to CCAAT-Enhancer-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to Epigenesis, Genetic

Share to Gene Rearrangement

Share to Gene Silencing

Share to Histone Deacetylase 1

Share to Liposarcoma

Source

Open in PubMed Open full text

Identifiers

PMID: 22328974
DOI: 10.1158/2159-8290.CD-11-0181
PMCID: PMC3274776

Genes

HDAC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22328974-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Frequent alterations and epigenetic silencing of differentiation pathway genes in structurally rearranged liposarcomas.PMID 22328974Read ↗

Integrated Genomic and Transcriptomic Analysis Revealed Mutation Patterns of De-differentiated Liposarcoma and LeiomyosarcomaSemantic proximity Read ↗

Integrated genomic and transcriptomic analysis revealed mutation patterns of de-differentiated liposarcoma and leiomyosarcoma.Semantic proximity Read ↗

Genomic landscape of liposarcoma.Semantic proximity Read ↗

Spatially-resolved single cell atlas of liposarcoma reveals lineage hierarchies, immune niches, and regulatory circuitsSemantic proximity Read ↗

Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy.Semantic proximity Read ↗

Genomic alterations and clinical outcomes in patients with dedifferentiated liposarcomaSemantic proximity Read ↗

Genetic, Epigenetic and Transcriptome Alterations in Liposarcoma for Target Therapy SelectionSemantic proximity Read ↗

Liposarcoma: Advances in Cellular and Molecular Genetics Alterations and Corresponding Clinical TreatmentSemantic proximity Read ↗

Copy Number Losses Define Subgroups of Dedifferentiated Liposarcoma with Poor Prognosis and Genomic InstabilitySemantic proximity Read ↗

Integrated exome and RNA sequencing of dedifferentiated liposarcoma.Semantic proximity Read ↗

Clinical and Molecular Spectrum of LiposarcomaSemantic proximity Read ↗

Genomic profiling of dedifferentiated liposarcoma compared to matched well-differentiated liposarcoma reveals higher genomic complexity and a common origin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.