Phenotypic transition in retroperitoneal liposarcoma: Bridging well-differentiated and dedifferentiated subtypes through genomics, epigenetics, and the tumor microenvironment.

Abstract excerpt

Retroperitoneal liposarcoma (RPL) presents a distinct "high-risk" disease spectrum, in which the phenotypic transition from well-differentiated liposarcoma (WDLPS) to dedifferentiated liposarcoma (DDLPS) constitutes a critical biological event leading to treatment failure and patient mortality. This review provides a systematic summary of the clinical features and multi-omics mechanisms underlying this...

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