Article

Enhanced epigenetic modulation via mRNA-encapsulated lipid nanoparticles enables targeted anti-inflammatory control

2025-02-28

Abstract excerpt

Temporal transcriptional modulation of immune-related genes offers powerful therapeutic potential for treating inflammatory diseases. Here, we introduce an enhanced zinc finger (ZF)-based transcriptional repressor delivered via lipid nanoparticles for controlling immune signaling pathways in vivo . By targeting Myd88, an essential adaptor molecule involved in immunity, our system demonstrates therapeutic efficacy...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ddafd8d4-4a3b-55d3-81f2-4344194ad145
DOI: 10.1101/2025.02.24.639996

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Enhanced epigenetic modulation via mRNA-encapsulated lipid nanoparticles enables targeted anti-inflammatory controlDOI 10.1101/2025.02.24.639996Read

Targeted lipid nanoparticles for RNA therapeutics and immunomodulation in leukocytes.Semantic proximity Read

Targeted delivery of RNA-based therapeutics enables functional analysis of macrophage subpopulationsSemantic proximity Read

Coordinated Tuning of Ionizable Lipids and Formulation Redirects mRNA Vaccines Toward Lymphoid-Specific CD4 <sup>+</sup> T Cell ImmunitySemantic proximity Read

T Lymphocyte-Macrophage Hybrid Membrane-Coated Biomimetic Nanoparticles Alleviate Myocarditis via Suppressing Pyroptosis by Targeting Gene SilencingSemantic proximity Read

Epigenetic control of multiple genes with a single lentiviral vector encoding transcriptional repressors fused to compact zinc finger arraysSemantic proximity Read

Engineered Self-Regulating Macrophages for Targeted Anti-inflammatory Drug DeliverySemantic proximity Read

Enhanced lung delivery of an immunostimulatory duplex RNA augments the antitumor activity by reshaping systemic cytokine pharmacodynamicsSemantic proximity Read

MRNA Vaccines and the Potential Risk of Connective Tissue DiseasesSemantic proximity Read

Epigenetic Regulation of Leukocyte Inflammatory Mediator Production Dictates Staphylococcus aureus Craniotomy Infection OutcomeSemantic proximity Read

Nucleic Acid-based Small Molecules as Targeted Transcription Therapeutics for ImmunoregulationSemantic proximity Read

Strategies to Modulate Immune Responses: A New Frontier for Gene TherapySemantic proximity Read

Lipid nanoparticle technology for therapeutic gene regulation in the liverSemantic proximity Read