Article

Microenvironmental Stiffness Induces Metabolic Reprogramming in Glioblastoma

2023-07-03

Abstract excerpt

The mechanical properties of solid tumors influence tumor cell phenotype and ability to invade into surrounding tissues. Using bioengineered scaffolds to provide a matrix microenvironment for patient-derived glioblastoma (GBM) spheroids, this study demonstrates that a soft, brain-like matrix induces GBM cells to shift to a glycolysis-weighted metabolic state which supports invasive behavior. We first show that ort...

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Literature Corpus work: ddad78cf-5d4e-5056-9eff-379ea08fcdd6
DOI: 10.1101/2023.07.03.547558

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