Article

Perivascular signals alter global gene expression profile of glioblastoma and response to temozolomide in a gelatin hydrogel

2018-03-03

Abstract excerpt

<h4>ABSTRACT</h4> Glioblastoma (GBM) is the most common primary malignant brain tumor, with patients exhibiting poor survival (median survival time: 15 months). Difficulties in treating GBM include not only the inability to resect the diffusively-invading tumor cells but also therapeutic resistance. The perivascular niche (PVN) within the GBM tumor microenvironment contributes significantly to tumor cell invasion...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ab7b80b9-86d0-5bde-8c57-933148e01954
DOI: 10.1101/273763

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Perivascular signals alter global gene expression profile of glioblastoma and response to temozolomide in a gelatin hydrogelDOI 10.1101/273763Read

Pericytes and Astrocytes Instruct Glioblastoma Invasion, Proliferation, and Therapeutic Response within an Engineered Brain Perivascular Niche ModelSemantic proximity Read

Mesenchymal-like glioma cells are enriched in the gelatin methacrylate hydrogelsSemantic proximity Read

3D Brain Vascular Niche Model Captures Invasive Behavior and Gene Signatures of GlioblastomaSemantic proximity Read

Understanding proneural–mesenchymal transition using patient-derived glioma stem-like cell (GSC) organoids and engineered extracellular matrixSemantic proximity Read

Impact of the biophysical features of a 3D gelatin microenvironment on glioblastoma malignancy.Semantic proximity Read

3D Brain Vascular Niche Model Captures Glioblastoma Infiltration, Dormancy, and Gene SignaturesSemantic proximity Read

Pan-cancer transcriptomic analysis of CNS tumor stroma identifies a population of perivascular fibroblasts that predict poor immunotherapy response in glioblastoma patientsSemantic proximity Read

Crosstalk between microglia and patient-derived glioblastoma cells inhibit invasion in a three-dimensional gelatin hydrogel modelSemantic proximity Read

Ex vivo Dynamics of Human Glioblastoma Cells in a Microvasculature-on-a-Chip System Correlates with Tumor Heterogeneity and Subtypes.Semantic proximity Read

Expanding Microgel Parameters to Model the Tumor Microenvironment and Examine Temozolomide Resistance in GlioblastomaSemantic proximity Read

Hyaluronic acid-functionalized gelatin hydrogels reveal extracellular matrix signals temper the efficacy of erlotinib against patient-derived glioblastoma specimensSemantic proximity Read

Dissecting TGF-β-induced glioblastoma invasion with engineered hyaluronic acid hydrogelsSemantic proximity Read