CMML2AML: machine-learning discovery of co-mutations and specific single mutations predictive of blast transformation in chronic myelomonocytic leukemia.

doi:10.1038/s41408-026-01491-1

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

CMML2AML: machine-learning discovery of co-mutations and specific single mutations predictive of blast transformation in chronic myelomonocytic leukemia.

Blood cancer journal - 12 Apr 2026

Fathima Saubia, Rokach Lior, Yousuf Muhammad, Faldu Priyansh, Alsugair Ali, Csizmar Clifford, Nakhleh Merry, Mangaonkar Abhishek A, Pardanani Animesh, Lanino Luca, Campagna Alessia, Maggioni Giulia, Farnoud Noushin, Rampal Raajit, Reichard Kaaren K, He Rong, Gangat Naseema, Patnaik Mrinal M, Della Porta Matteo G, Tefferi Ayalew

Abstract excerpt

Contemporary risk models in chronic myelomonocytic leukemia (CMML) focus on the prognostic relevance of individual rather than concurrent mutations. In the current study of 605 Mayo Clinic patients with CMML, we applied machine-learning algorithms in order to examine the influence of cooperative mutational interactions on blast transformation (BT). A hierarchical clustering algorithm was developed and tailored...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blast Crisis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Clustering Algorithms

Share to SETBP1 gene

Share to Leukemia, Myelomonocytic, Chronic

Share to Machine Learning

Share to Mutation

Share to Nucleophosmin

Share to Prognosis

Source

Open in PubMed Open full text

Identifiers

PMID: 41965730
DOI: 10.1038/s41408-026-01491-1
PMCID: PMC13181037

Genes

ASXL1
NPM1
RUNX1
BCOR
NRAS
SETBP1
DNMT3A
JAK2
PHF6
SRSF2
TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CMML2AML: machine-learning discovery of co-mutations and specific single mutations predictive of blast transformation in chronic myelomonocytic leukemia.PMID 41965730Read ↗

BLAST: a globally applicable and molecularly versatile survival model for chronic myelomonocytic leukemia.Semantic proximity Read ↗

Molecular patterns identify distinct subclasses of myeloid neoplasiaSemantic proximity Read ↗

Integrating clinical features and genetic lesions in the risk assessment of patients with chronic myelomonocytic leukemia.Semantic proximity Read ↗

Molecular patterns identify distinct subclasses of myeloid neoplasia.Semantic proximity Read ↗

Machine Learning Allows the Identification of New Co-Mutational Patterns with Prognostic Implications in NPM1 Mutated AML - Results of the European Harmony AllianceSemantic proximity Read ↗

Blast phenotype and comutations in acute myeloid leukemia with mutated NPM1 influence disease biology and outcome.Semantic proximity Read ↗

Mutational architecture defines disease behaviour in an Indian cohort of Myeloproliferative Neoplasms: Foundations for a Genomics-first classification.Semantic proximity Read ↗

Frequency and impact of somatic co-occurring mutations on post-transplant outcomes in acute myeloid leukemia: a multicenter registry analysis on behalf of the EBMT ALWP.Semantic proximity Read ↗

Frequency and Impact of Somatic Co-occurring Mutations on Post-Transplant Outcomes in Acute Myeloid Leukemia: A Multicenter Registry Analysis on Behalf of the EBMT ALWPSemantic proximity Read ↗

CNL and aCML should be considered as a single entity based on molecular profiles and outcomes.Semantic proximity Read ↗

The mutational landscape in chronic myelomonocytic leukemia and its impact on allogeneic hematopoietic cell transplantation outcomes: a Center for Blood and Marrow Transplantation Research (CIBMTR) analysis.Semantic proximity Read ↗

Prognostic score including gene mutations in chronic myelomonocytic leukemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.