Article

A systematic genome-wide mapping of oncogenic mutation selection during CRISPR-Cas9 genome editing

2021-02-10

Abstract excerpt

<title>Abstract</title> <p>Recent studies have reported that genome editing by CRISPR–Cas9 induces a DNA damage response mediated by <italic>p53</italic> in primary cells hampering their growth. This could lead to a selection of cells with pre-existing <italic>p53</italic> mutations. In this study, employing an integrated computational and experimental framework, we systematically investigated the possibility of...

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Literature Corpus work: 3eecd7d8-1778-5d46-bdd9-b23f86f6647b
DOI: 10.21203/rs.3.rs-199044/v1

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