Article

Transcription factor dynamics, oscillation, and functions in human enteroendocrine cell differentiation

2024-01-09

Abstract excerpt

<h4>Summary</h4> Enteroendocrine cells (EECs), which secrete serotonin (enterochromaffin cells, EC) or a dominant peptide hormone, serve vital physiologic functions. As with any adult human lineage, the basis for terminal cell diversity remains obscure. We replicated human EEC differentiation in vitro , mapped transcriptional and chromatin dynamics that culminate in discrete cell types, and studied abundant EEC...

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Literature Corpus work: 5f41dd67-f4f1-547a-8ce1-bf812a9001d4
DOI: 10.1101/2024.01.09.574746

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