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Omega-3 polyunsaturated fatty acids protect neurological function after traumatic brain injury by suppressing microglial transformation to the proinflammatory phenotype and activating exosomal NGF/TrkA signaling

2022-11-28

Abstract excerpt

<title>Abstract</title> <p>The transformation of microglia to a pro-inflammatory phenotype at the site of traumatic brain injury (TBI) drives the progression of secondary neurodegeneration and irreversible neurological impairment. Omega-3 polyunsaturated fatty acids (PUFAs) have been shown to suppress this phenotype transformation, thereby reducing neuroinflammation following TBI, but the molecular mechanisms are...

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Literature Corpus work
dd8715e5-c75f-5406-9f5f-9046ff01e780
DOI
10.21203/rs.3.rs-2267425/v1
Open publication

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