Article

Ancient and Animal-Specific Regulatory Modes of EWS::FLI1 Revealed by a Minimal Yeast Model

2025-10-23

Abstract excerpt

<h4>ABSTRACT</h4> Ewing sarcoma (EwS) is an aggressive, human-exclusive tumor typically driven by the EWS::FLI1 fusion protein. To assess whether the neomorphic functions of EWS::FLI1 are fundamentally dependent on evolutionarily recent cofactors such as ETS transcription factors (ETS-TFs), Plycomb group (PcG) proteins, CBP/p300, or specific subunits of the BAF complex, we expressed EWS::FLI1 in the model organis...

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Literature Corpus work: dd7fbae4-4501-5a5a-a7f2-5ed265806ce6
DOI: 10.1101/2025.10.22.680884

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