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Article

Metallothionein 2A interacts with the kinase domain of PKCmu in prostate cancer.

Biochemical and biophysical research communications - 24 Oct 2003

Rao Prema S, Jaggi Meena, Smith David J, Hemstreet George P, Balaji K C

Abstract excerpt

Prostate cancer (PC) patients die from progression to androgen independence (AI) and chemoresistance (CR). Protein kinase Cmu (PKCmu) a novel member of the PKC family of signal transduction proteins is downregulated in AI PC. Studying PKCmu interactors in the yeast two-hybrid system identified metallothionein 2A (MT 2A) as an interactor of PKCmu kinase domain (KD) in PC, which was quantified by beta-gal assay,...

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Androgens
beta-Galactosidase
Metallothionein
Oligonucleotides, Antisense
Precipitin Tests

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Kinase C

Two-Hybrid System Techniques

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PMID: 14550308
DOI: 10.1016/j.bbrc.2003.09.118

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