Article

Elucidating mechanisms of genetic cross-disease associations: an integrative approach implicates protein C as a causal pathway in arterial and venous diseases

2020-03-20

Abstract excerpt

Genome-wide association studies have identified many individual genetic loci associated with multiple complex traits and common diseases. There are, however, few examples where the molecular basis of such pleiotropy has been elucidated. To address this challenge, we describe an integrative approach, focusing on the p.Ser219Gly (rs867186 A>G) variant in the PROCR gene (encoding the endothelial protein C receptor, E...

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Literature Corpus work: dd636656-3706-5fda-a4d2-3d8bdfc4af4c
DOI: 10.1101/2020.03.16.20036822

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