The endothelial protein C receptor (PROCR) Ser219Gly variant and risk of common thrombotic disorders: a HuGE review and meta-analysis of evidence from observational studies.

doi:10.1182/blood-2011-10-383448

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Article

The endothelial protein C receptor (PROCR) Ser219Gly variant and risk of common thrombotic disorders: a HuGE review and meta-analysis of evidence from observational studies.

Blood - 8 Mar 2012

Dennis Jessica, Johnson Candice Y, Adediran Adeniyi Samuel, de Andrade Mariza, Heit John A, Morange Pierre-Emmanuel, Trégouët David-Alexandre, Gagnon France

Abstract excerpt

The endothelial protein C receptor (EPCR) limits thrombus formation by enhancing activation of the protein C anticoagulant pathway, and therefore may play a role in the etiology of thrombotic disorders. The rs867186 single-nucleotide polymorphism in the PROCR gene (g.6936A > G, c.4600A > G), resulting in a serine-to-glycine substitution at codon 219, has been associated with reduced activation of the protein C...

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PMID: 22251481
DOI: 10.1182/blood-2011-10-383448
PMCID: PMC3311261

Genes

PROCR

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