Article
Global downstream pathway analysis reveals a dependence of oncogenic NF-E2-related factor 2 mutation on the mTOR growth signaling pathway.
Cancer research - 15 Nov 2010
Shibata Tatsuhiro, Saito Shigeru, Kokubu Akiko, Suzuki Takafumi, Yamamoto Masayuki, Hirohashi Setsuo
Abstract excerpt
In multicellular organisms, adaptive responses to oxidative stress are regulated by NF-E2-related factor 2 (NRF2), a master transcription factor of antioxidant genes and phase II detoxifying enzymes. Aberrant activation of NRF2 by either loss-of-function mutations in the Keap1 gene or gain-of-function mutations in the Nrf2 gene occurs in a wide range of human cancers, but details of the biological consequences of...
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