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Article

Multifaceted roles of TAX1BP1 in autophagy

26 Apr 2022

Abstract excerpt

TAX1BP1 is a selective macroautophagy/autophagy receptor that plays a central role in host defense to pathogens and in regulating the innate immune system. TAX1BP1 facilitates the xenophagic clearance of pathogenic bacteria such as Salmonella typhimurium and Mycobacterium tuberculosis and regulates TLR3 (toll-like receptor 3)-TLR4 and DDX58/RIG-I-like receptor (RLR) signaling by targeting TICAM1 and MAVS for...

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PMID: 35470757
DOI: 10.1080/15548627.2022.2070331

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