Article

ADAR1 can drive Multiple Myeloma progression by acting both as an RNA editor of specific transcripts and as a DNA mutator of their cognate genes

2020-02-12

Abstract excerpt

<h4>ABSTRACT</h4> RNA editing is an epitranscriptomic modification of emerging relevance to disease development and manifestations. ADAR1, which resides on human chromosome 1q21, is an RNA editor whose over-expression, either by interferon (IFN) induction or through gene amplification, is associated with increased editing and poor outcomes in Multiple Myeloma (MM). Here we explored the role of ADAR1 in the contex...

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Literature Corpus work: dd4f0f35-510e-54b1-a4b1-a8ac5847cd95
DOI: 10.1101/2020.02.11.943845

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