Article

Mapping Disease Transitions from Premalignant, Asymptomatic to Advanced Myeloma through Integrative Epigenomic and Transcriptional Analyses

2026-06-08

Abstract excerpt

<h4> Abstract </h4> Multiple myeloma (MM) evolves from asymptomatic precursor conditions through progressive genetic and epigenetic remodeling, yet the regulatory mechanisms driving the development toward more active stages of the disease remain poorly understood. Here, we integrated bulk-based paired chromatin accessibility and activation, and transcriptomic profiling across disease stages to map regulatory rem...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: db89777b-4d72-5b7b-9543-5f2923564aaa
DOI: 10.64898/2026.06.03.729851

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mapping Disease Transitions from Premalignant, Asymptomatic to Advanced Myeloma through Integrative Epigenomic and Transcriptional AnalysesDOI 10.64898/2026.06.03.729851Read

Active enhancer and chromatin accessibility landscapes chart the regulatory network of primary multiple myelomaSemantic proximity Read

Chromatin-based, in cis and in trans regulatory rewiring underpins distinct oncogenic transcriptomes in multiple myelomaSemantic proximity Read

Chromatin activation as a unifying principle underlying pathogenic mechanisms in multiple myelomaSemantic proximity Read

Dynamic super-enhancer core regulatory circuits and epigenetic landscapes drive malignant progression and refractory disease in multiple myelomaSemantic proximity Read

MAF functions as a pioneer transcription factor that initiates and sustains myelomagenesisSemantic proximity Read

Multiple Myeloma DREAM Challenge Reveals Epigenetic Regulator <i>PHF19</i> As Marker of Aggressive DiseaseSemantic proximity Read

Definers and drivers of functional high-risk multiple myeloma: insights from genomic, transcriptomic, and immune profilingSemantic proximity Read

Mapping the Molecular Terrain of Multiple Myeloma: A Focus on Inflammation-Driven PathwaysSemantic proximity Read

Selective Enhancer Gain-of-Function Deregulates MYC Expression in Multiple MyelomaSemantic proximity Read

Single cell characterization of myeloma and its precursor conditions reveals transcriptional signatures of early tumorigenesisSemantic proximity Read

Interpreting the molecular biology and clinical behavior of multiple myeloma in the context of global gene expression profilingSemantic proximity Read

Chromatin Accessibility Identifies Regulatory Elements Predictive of Gene Expression and Disease Outcome in Multiple MyelomaSemantic proximity Read