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Article

Methylation variability and LINE-1 activation in multiple myeloma

2025-07-26

Abstract excerpt

Multiple myeloma (MM) is a type of hematological cancer that arises from uncontrolled proliferation of plasma cells. In addition to frequent genetic mutations, malignant plasma cells are characterized by alterations to the epigenome. Myeloma cells display a genome-wide loss of DNA methylation and a corresponding increase in ‘active’ chromatin modifications. The dramatic epigenetic remodeling that occurs in cancer...

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Identifiers and source

Literature Corpus work
25ebb88b-3846-529d-ad42-cd52ee6d53f4
DOI
10.1101/2025.07.22.666173
Open publication

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Methylation variability and LINE-1 activation in multiple myelomaDOI 10.1101/2025.07.22.666173
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