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HA stability regulates H1N1 influenza virus replication and pathogenicity in mice by modulating type I interferon responses in dendritic cells

2019-08-22

Abstract excerpt

<h4>ABSTRACT</h4> Hemagglutinin (HA) stability, or the pH at which the HA is activated to cause membrane fusion, has been associated with the replicative fitness, pathogenicity, transmissibility, and interspecies adaptation of influenza A viruses. Here, we investigated several mechanisms by which a destabilizing HA mutation, Y17H (activation pH 6.0), may attenuate virus replication and pathogenicity in DBA/2 mice...

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Literature Corpus work
dd439a1e-bdbb-5a7f-9a04-4f7e30820fac
DOI
10.1101/744052
Open publication

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HA stability regulates H1N1 influenza virus replication and pathogenicity in mice by modulating type I interferon responses in dendritic cellsDOI 10.1101/744052
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