Article
The pH of activation of the hemagglutinin protein regulates H5N1 influenza virus pathogenicity and transmissibility in ducks.
Journal of virology - 1 Feb 2010
Reed Mark L, Bridges Olga A, Seiler Patrick, Kim Jeong-Ki, Yen Hui-Ling, Salomon Rachelle, Govorkova Elena A, Webster Robert G, Russell Charles J
Abstract excerpt
While the molecular mechanism of membrane fusion by the influenza virus hemagglutinin (HA) protein has been studied extensively in vitro, the role of acid-dependent HA protein activation in virus replication, pathogenesis, and transmission in vivo has not been characterized. To investigate the biological significance of the pH of activation of the HA protein, we compared the properties of four recombinant viruses...
Topics
- Animals
- Bird Diseases
- Ducks
- Hemagglutinin Glycoproteins, Influenza Virus
- Hydrogen-Ion Concentration
- Influenza A Virus, H5N1 Subtype
- Membrane Fusion
- Mutation
- Recombination, Genetic