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Article

Hemagglutinin Stability Regulates H1N1 Influenza Virus Replication and Pathogenicity in Mice by Modulating Type I Interferon Responses in Dendritic Cells.

Journal of virology - 17 Jan 2020

Russier Marion, Yang Guohua, Briard Benoit, Meliopoulos Victoria, Cherry Sean, Kanneganti Thirumala-Devi, Schultz-Cherry Stacey, Vogel Peter, Russell Charles J

Abstract excerpt

Hemagglutinin (HA) stability, or the pH at which HA is activated to cause membrane fusion, has been associated with the replication, pathogenicity, transmissibility, and interspecies adaptation of influenza A viruses. Here, we investigated the mechanisms by which a destabilizing HA mutation, Y17H (activation pH, 6.0), attenuates virus replication and pathogenicity in DBA/2 mice compared to wild-type (WT) virus...

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Identifiers

PMID: 31694942
DOI: 10.1128/JVI.01423-19
PMCID: PMC7000976

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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