Article

Random mutagenesis of influenza hemagglutinin identifies new sites which modulate its acid-stability and cleavability

2025-07-25

Abstract excerpt

<h4>ABSTRACT</h4> The structural instability of influenza hemagglutinin (HA) is related to its function in low pH-mediated membrane fusion, which requires prior cleavage of the premature HA0 by a host protease. The precise determinants underlying the stability and cleavability of HA remain to be fully understood and have implications for risk assessment of zoonotic influenza A viruses (IAV), viral transmissibilit...

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Literature Corpus work: 718b150c-59f6-502f-8bf4-9a874e7a4628
DOI: 10.1101/2025.07.25.666873

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