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Article

Age-associated motor and visuo-spatial learning phenotype in Dyrk1A heterozygous mutant mice.

Neurobiology of disease - 1 Nov 2009

Arqué Glòria, de Lagrán María Martínez, Arbonés Maria L, Dierssen Mara

Abstract excerpt

Dual-specificity tyrosine-regulated kinase 1A (DYRK1A) is a candidate gene for the Down syndrome neurological defects and may be involved in the progression of Alzheimer's disease. Heterozygous mice for Dyrk1A (Dyrk1A+/-) exhibit decreased brain size, motor abnormalities and cognitive deficits in the adult. However, there is no information about the mutant phenotype in old ages. Here we analyze the impact of...

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Identifiers

PMID: 19660545
DOI: 10.1016/j.nbd.2009.07.027

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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