Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hippocampal TET1 and TET2 Expression and DNA Hydroxymethylation Are Affected by Physical Exercise in Aged Mice

19 Apr 2018

Abstract excerpt

The function of 5-hydroxymethylcytosine (5hmC) is poorly understood. 5hmC is an epigenetic modification of DNA, resulting from the oxidation of 5-methylcytosine (5mC) by the Fe2+ and 2-oxoglutarate-dependent, ten-eleven translocation methylcytosine dioxygenases (TET1, TET2 and TET3). Recent evidence suggests that, in addition to being an intermediate in active demethylation, 5hmC may also have an epigenetic role....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Childhood Cancer Survivors' Quality of Life
Share to Epigenetics and DNA Methylation
Share to Genetic Syndromes and Imprinting

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29732371
DOI: 10.3389/fcell.2018.00045

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hippocampal TET1 and TET2 Expression and DNA Hydroxymethylation Are Affected by Physical Exercise in Aged MicePMID 29732371Read ↗

The Role of 5-Hydroxymethylcytosine in Aging and Alzheimer’s Disease: Current Status and Prospects for Future StudiesSemantic proximity Read ↗

TET1 controls CNS 5-methylcytosine hydroxylation, active DNA demethylation, gene transcription, and memory formation.Semantic proximity Read ↗

Alterations in DNA 5-hydroxymethylation Patterns in the Hippocampus of an Experimental Model of Refractory EpilepsySemantic proximity Read ↗

Alterations in DNA 5-hydroxymethylation patterns in the hippocampus of an experimental model of chronic epilepsySemantic proximity Read ↗

TET1 displays catalytic and non-catalytic functions in the adult mouse cortex.Semantic proximity Read ↗

Ten-eleven translocation 1 Mediated-DNA Hydroxymethylation is Required for Myelination and Remyelination in the Mouse BrainSemantic proximity Read ↗

A single-cell transcriptomic analysis of the mouse hippocampus after voluntary exerciseSemantic proximity Read ↗

Environmental Enrichment Improves Cognitive Deficits, AD Hallmarks and Epigenetic Alterations Presented in 5xFAD Mouse ModelSemantic proximity Read ↗

Epigenetic rejuvenation of the hippocampus by environmental enrichmentSemantic proximity Read ↗

Developmental Iron Deficiency Dysregulates TET Activity and DNA Hydroxymethylation in the Rat Hippocampus and CerebellumSemantic proximity Read ↗

The role of 5‐hydroxymethylcytosine in mitochondria after ischemic strokeSemantic proximity Read ↗

Alteration in 5-hydroxymethylcytosine-mediated epigenetic regulation leads to Purkinje cell vulnerability in ATM deficiencySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.