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Article

Improved rotorod performance and hyperactivity in mice deficient in a protein repair methyltransferase.

Behavioural brain research - 12 Aug 2004

Vitali Ryan, Clarke Steven

Abstract excerpt

The protein L-isoaspartate (D-aspartate)-O-methyltransferase participates in the repair of age-induced protein damage by initiating the conversion of abnormal aspartyl residues within proteins to normal L-aspartyl residues. Previous studies have shown that mice deficient in the gene encoding this enzyme (Pcmt1-/-) accumulate damaged proteins, have altered levels of brain S-adenosylmethionine (AdoMet) and...

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Source

Identifiers

PMID: 15219714
DOI: 10.1016/j.bbr.2003.11.007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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