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Investigating cytotoxic and inflammatory human IL-7 receptor low effector memory CD8+ T cells in lupus

25 Aug 2025

Abstract excerpt

Background This study aims to interrogate the implications of CD8 + T cells in lupus by examining CD8 + T cell heterogeneity and assessing the significance of this heterogeneity in promoting inflammation and tissue damage. Methods Our own and publicly available RNA-seq and microarray data from the peripheral blood and kidney tissues of patients with lupus were analysed. Imaging Mass Cytometry (IMC) analysis of...

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PMID: 40857939
DOI: 10.1016/j.ebiom.2025.105898

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