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Leukocyte Chemoattractant Receptors in Human Disease Pathogenesis

11 Nov 2014

Abstract excerpt

Combinations of leukocyte attractant ligands and cognate heptahelical receptors specify the systemic recruitment of circulating cells by triggering integrin-dependent adhesion to endothelial cells, supporting extravasation, and directing specific intratissue localization via gradient-driven chemotaxis. Chemoattractant receptors also control leukocyte egress from lymphoid organs and peripheral tissues. In this...

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PMID: 25387059
DOI: 10.1146/annurev-pathol-012513-104640

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