Article

The CD73 immune checkpoint promotes tumor cell metabolic fitness

2022-12-02

Abstract excerpt

CD73 is an ectonucleotidase overexpressed on tumor cells that suppresses anti-tumor immunity. Accordingly, several CD73 inhibitors are currently being evaluated in the clinic, including in large randomized clinical trials. Yet, the tumor cell-intrinsic impact of CD73 remain largely uncharacterized. Using metabolomics, we discovered that CD73 significantly enhances tumor cell mitochondrial respiration and aspartate...

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Literature Corpus work: 4cb18ca6-42ef-5c44-bf76-6339cd29898c
DOI: 10.1101/2022.11.29.518350

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