Article

The sonic hedgehog signaling inhibitor cyclopamine improves pulmona ry arterial hypertension via regulating the bone morphogenetic protein receptor 2 pathway

2024-09-16

Abstract excerpt

<title>Abstract</title> <p>Pulmonary arterial hypertension (PAH) is a severe and progressive disease with hallmarks of pulmonary vascular remodeling and bone morphogenetic protein receptor 2 (BMPR2) mutation. Recent studies indicate Sonic hedgehog (SHH) signaling is involved in the proliferation of human pulmonary arterial smooth muscle cells (hPASMCs) but the role of the SHH signaling inhibitor cyclopamine in mo...

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Literature Corpus work: dd1ff4f8-6fdd-5ab8-bef6-e5a9e346ad1e
DOI: 10.21203/rs.3.rs-4881852/v1

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