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Article

MicroRNA-140-5p and SMURF1 regulate pulmonary arterial hypertension.

The Journal of clinical investigation - 1 Jul 2016

Rothman Alexander M K, Arnold Nadine D, Pickworth Josephine A, Iremonger James, Ciuclan Loredana, Allen Robert M H, Guth-Gundel Sabine, Southwood Mark, Morrell Nicholas W, Thomas Matthew, Francis Sheila E, Rowlands David J, Lawrie Allan

Abstract excerpt

Loss of the growth-suppressive effects of bone morphogenetic protein (BMP) signaling has been demonstrated to promote pulmonary arterial endothelial cell dysfunction and induce pulmonary arterial smooth muscle cell (PASMC) proliferation, leading to the development of pulmonary arterial hypertension (PAH). MicroRNAs (miRs) mediate higher order regulation of cellular function through coordinated modulation of mRNA...

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Share to Hypertension, Pulmonary
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27214554
DOI: 10.1172/JCI83361
PMCID: PMC4922709

Genes

PAH
SMURF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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