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Article

Enhancer of zeste homolog 2 induces pulmonary artery smooth muscle cell proliferation.

PloS one - 1 Jan 2012

Aljubran Salman A, Cox Ruan, Tamarapu Parthasarathy Prasanna, Kollongod Ramanathan Gurukumar, Rajanbabu Venugopal, Bao Huynh, Mohapatra Shyam S, Mohapatra Shyam M, Lockey Richard, Kolliputi Narasaiah

Abstract excerpt

INTRODUCTION: Pulmonary Arterial Hypertension (PAH) is a progressively devastating disease characterized by excessive proliferation of the Pulmonary Arterial Smooth Muscle Cells (PASMCs). Studies suggest that PAH and cancers share an apoptosis-resistant state featuring excessive cell proliferation. The proliferation of cancer cells is mediated by increased expression of Enhancer of Zeste Homolog 2 (EZH2), a...

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Source

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Identifiers

PMID: 22662197
DOI: 10.1371/journal.pone.0037712
PMCID: PMC3360676

Genes

PAH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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