Article
Sildenafil potentiates bone morphogenetic protein signaling in pulmonary arterial smooth muscle cells and in experimental pulmonary hypertension.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jan 2013
Yang Jun, Li Xiaohui, Al-Lamki Rafia S, Wu Changxin, Weiss Astrid, Berk Joachim, Schermuly Ralph T, Morrell Nicholas W
Abstract excerpt
OBJECTIVE: Mutations in the bone morphogenetic protein type II receptor (BMPR-II) are responsible for the majority of cases of heritable pulmonary arterial hypertension (PAH), and BMPR-II deficiency contributes to idiopathic and experimental forms of PAH. Sildenafil, a potent type-5 nucleotide-dependent phosphodiesterase inhibitor, is an established treatment for PAH, but whether sildenafil affects bone...
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