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Article

Targeting RUNX1 as a novel treatment modality for pulmonary arterial hypertension

6 Jan 2022

Abstract excerpt

AIMS: Pulmonary arterial hypertension (PAH) is a fatal disease without a cure. Previously, we found that transcription factor RUNX1-dependent haematopoietic transformation of endothelial progenitor cells may contribute to the pathogenesis of PAH. However, the therapeutic potential of RUNX1 inhibition to reverse established PAH remains unknown. In the current study, we aimed to determine whether RUNX1 inhibition...

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PMID: 35018410
DOI: 10.1093/cvr/cvac001

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