Article
Nuclear envelope proteins and chromatin arrangement: a pathogenic mechanism for laminopathies.
European journal of histochemistry : EJH - 1 Jan 2000
Maraldi N M, Lattanzi G, Capanni C, Columbaro M, Merlini L, Mattioli E, Sabatelli P, Squarzoni S, Manzoli F A
Abstract excerpt
The involvement of the nuclear envelope in the modulation of chromatin organization is strongly suggested by the increasing number of human diseases due to mutations of nuclear envelope proteins. A common feature of these diseases, named laminopathies, is the occurrence of major chromatin defects. We previously reported that cells from laminopathic patients show an altered nuclear profile, and loss or detachment...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.