Article

GSDMD gene knockout alleviates hyperoxia-induced hippocampal brain injury in neonatal mice

2023-06-15

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Neonatal hyperoxia exposure is associated with brain injury and poor neurodevelopment outcomes in preterm infants. Our previous studies in neonatal rodent models have shown that hyperoxia stimulates the brain’s inflammasome pathway, leading to the activation of gasdermin D (GSDMD), a key executor of pyroptotic inflammatory cell death. Moreover, we found inhibiti...

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Literature Corpus work: dd07d90a-8b58-52c8-bf79-590f7841afa1
DOI: 10.21203/rs.3.rs-3055085/v1

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