Article

A Novel Noninvasive Murine Model of Neonatal Hypoxic Ischemic Encephalopathy Demonstrates Developmental Delay and Motor Deficits with Activation of Inflammatory Pathways in Monocytes

2024-07-30

Abstract excerpt

Neonatal hypoxic ischemic encephalopathy (HIE) occurs in 1.5 per 1000 live births, leaving affected children with long-term motor and cognitive deficits. Few animal models of HIE incorporate maternal immune activation (MIA) despite the significant risk MIA poses to HIE incidence and diagnosis. Our non-invasive model of HIE pairs late gestation MIA with postnatal hypoxia. HIE pups exhibited a trend toward smaller o...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a09a08ff-7ba7-5ee1-8699-a3261277c38d
DOI: 10.20944/preprints202407.2364.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A Novel Noninvasive Murine Model of Neonatal Hypoxic Ischemic Encephalopathy Demonstrates Developmental Delay and Motor Deficits with Activation of Inflammatory Pathways in MonocytesDOI 10.20944/preprints202407.2364.v1Read

Hypoxia-Ischemia During a Neonatal Sensitive Period Alters Purkinje Neuron Dendritic Complexity Differently in Male and Female RatsSemantic proximity Read

Single-cell Transcriptomic Profiling of Brains in Newborn Rats Following Hypoxic Ischemic EncephalopathySemantic proximity Read

Accumulation of Lipid Droplets in Microglia following Neonatal Brain Hypoxia-IschemiaSemantic proximity Read

A temporal map of maternal immune activation-induced changes reveals a shift in neurodevelopmental timing and perturbed cortical development in miceSemantic proximity Read

Physiological roles of embryonic microglia and their perturbation by maternal inflammationSemantic proximity Read

Umbilical cord blood derived microglia-like cells to model COVID-19 exposureSemantic proximity Read

Fetal hypoxia results in sex- and cell type-specific alterations in neonatal transcription in rat oligodendrocyte precursor cells, microglia, neurons, and oligodendrocytesSemantic proximity Read

Hypoxia versus immune depletion - immune profiling and treatment cessation provide mechanistic insights and considerations for translation in Leigh syndromeSemantic proximity Read

How Does Maternal Immune Activity Affect Fetal Survival and Brain Development?: The Critical Roles of IL-17A and MicrogliaSemantic proximity Read

Sex differences in the effects of PARP inhibition on microglial phenotypes following neonatal stroke.Semantic proximity Read

Genetic and epigenetic contributors and mimickers of phenotypic hypoxic-ischemic encephalopathy (HIE).Semantic proximity Read

Effects of human umbilical cord mesenchymal stem cell (hUC-MSC)-derived exosomes on HIBD immunoinflammation in neonatal ratsSemantic proximity Read