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Humanized-VHH Transbodies that Inhibit HCV Protease and Replication

20 Apr 2015

Abstract excerpt

There is a need for safe and broadly effective anti-HCV agents that can cope with genetic multiplicity and mutations of the virus. In this study, humanized-camel VHHs to genotype 3a HCV serine protease were produced and were linked molecularly to a cell penetrating peptide, penetratin (PEN). Human hepatic (Huh7) cells transfected with the JFH-1 RNA of HCV genotype 2a and treated with the cell penetrable...

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PMID: 25903832
DOI: 10.3390/v7042030

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