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Article

An alpaca nanobody inhibits hepatitis C virus entry and cell-to-cell transmission.

Hepatology (Baltimore, Md.) - 1 Sept 2013

Tarr Alexander W, Lafaye Pierre, Meredith Luke, Damier-Piolle Laurence, Urbanowicz Richard A, Meola Annalisa, Jestin Jean-Luc, Brown Richard J P, McKeating Jane A, Rey Felix A, Ball Jonathan K, Krey Thomas

Abstract excerpt

UNLABELLED: Severe liver disease caused by chronic hepatitis C virus is the major indication for liver transplantation. Despite recent advances in antiviral therapy, drug toxicity and unwanted side effects render effective treatment in liver-transplanted patients a challenging task. Virus-specific therapeutic antibodies are generally safe and well-tolerated, but their potential in preventing and treating...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 23553604
DOI: 10.1002/hep.26430

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