Article

The MuSK-BMP pathway maintains myofiber size in slow muscle through regulation of Akt- mTOR signaling

2023-02-27

Abstract excerpt

Myofiber size regulation is critical in health, disease, and aging. MuSK (muscle-specific kinase) is a BMP (bone morphogenetic protein) co-receptor that promotes and shapes BMP signaling. MuSK is expressed at all neuromuscular junctions and is also present extrasynaptically in the slow soleus muscle. To investigate the role of the MuSK-BMP pathway in vivo we generated mice lacking the BMP-binding MuSK Ig3 domain....

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Literature Corpus work: dced3359-40ad-5de1-856e-da36dba8e085
DOI: 10.21203/rs.3.rs-2613527/v1

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