Article

Klotho deficiency promotes skeletal muscle weakness and is associated with impaired motor unit connectivity

2025-06-17

Abstract excerpt

<h4>ABSTRACT</h4> Muscle wasting and weakness are important clinical problems that impact quality of life and health span by restricting mobility and independence, and by increasing the risk for physical disability. The molecular basis for this has not been fully determined. Klotho expression is downregulated in conditions associated with muscle wasting, including aging, chronic kidney disease, and myopathy. The...

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Literature Corpus work: 418a4813-8a57-565b-a080-0716c5a839b8
DOI: 10.1101/2025.06.11.659129

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