Article

Dyrk1b is a key Regulatory Kinase Integrating Fgf, Shh and mTORC1 signaling in Skeletal Muscle Development and Homeostasis

2020-04-23

Abstract excerpt

<h4>ABSTRACT</h4> The advent of human genetics has provided unprecedented opportunities for discovery of novel disease pathways. Mutations in DYRK1B have been associated with metabolic syndrome and sarcopenic obesity in humans, underscoring the critical role of the encoded protein in skeletal muscle development and homeostasis. By the novel creation of Dyrk1b knockout zebrafish models we demonstrate that Dyrk1b...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3baec66d-7df6-555c-a478-f0166df5fe20
DOI: 10.1101/2020.04.22.055947

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Dyrk1b is a key Regulatory Kinase Integrating Fgf, Shh and mTORC1 signaling in Skeletal Muscle Development and HomeostasisDOI 10.1101/2020.04.22.055947Read

New insights into the roles for DYRK family in mammalian development and congenital diseasesSemantic proximity Read

SRSF2 is a key player in orchestrating the directional migration and differentiation of MyoD progenitors during skeletal muscle developmentSemantic proximity Read

FOXK2 in skeletal muscle development: a new pathogenic gene for congenital myopathy with ptosis.Semantic proximity Read

The MuSK-BMP pathway maintains myofiber size in slow muscle through regulation of Akt-mTOR signalingSemantic proximity Read

Pharmacological PIK3C2B inhibition rescues XLMTM phenotype in mouse models and identifies molecular markers of disease.Semantic proximity Read

MyoD-Cre driven alterations in K-Ras and p53 lead to a mouse model with histological and molecular characteristics of human rhabdomyosarcoma with direct translational applicationsSemantic proximity Read

Ccndbp1 is a new positive regulator of skeletal myogenesis.Semantic proximity Read

Functions of SRPK , CLK and DYRK kinases in stem cells, development, and human developmental disordersSemantic proximity Read

Transcriptomic Characterisation of the Molecular Mechanisms Induced by RGMa During Skeletal Muscle Hyperplasia and HypertrophySemantic proximity Read

Muscle dysfunction caused by loss of<i>Magel2</i>in a mouse model of Prader-Willi and Schaaf-Yang syndromesSemantic proximity Read

A form of the metabolic syndrome associated with mutations in DYRK1B.Semantic proximity Read

The MuSK-BMP pathway maintains myofiber size in slow muscle through regulation of Akt- mTOR signalingSemantic proximity Read