Article

PIM Kinases Alter Mitochondrial Dynamics and Chemosensitivity in Lung Cancer

2019-12-05

Abstract excerpt

Resistance to chemotherapy represents a major obstacle to the successful treatment of non-small cell lung cancer (NSCLC). The goal of this study was to determine how PIM kinases impact mitochondrial dynamics, ROS production, and response to chemotherapy in lung cancer. Live cell imaging and microscopy were used to determine the effect of PIM loss or inhibition on mitochondrial phenotype and ROS. Inhibition of PIM...

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Literature Corpus work: dcea0290-63ff-52ed-85f2-ade491a1d1af
DOI: 10.1101/863811

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