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MFF Regulation of Mitochondrial Cell Death Is a Therapeutic Target in Cancer

3 Oct 2019

Abstract excerpt

Abstract The regulators of mitochondrial cell death in cancer have remained elusive, hampering the development of new therapies. Here, we showed that protein isoforms of mitochondrial fission factor (MFF1 and MFF2), a molecule that controls mitochondrial size and shape, that is, mitochondrial dynamics, were overexpressed in patients with non–small cell lung cancer and formed homo- and heterodimeric complexes with...

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PMID: 31582380
DOI: 10.1158/0008-5472.can-19-1982

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