Article

Reactivation of DRP1 plays a functional role in resistance to MEK inhibition in pancreatic cancer cells

2026-05-22

Abstract excerpt

<h4>Background</h4> In RAS-mutant tumors, ERK phosphorylates the mitochondrial fission GTPase DRP1 to promote mitochondrial fission. DRP1 activity is tumor-promoting in pancreatic and other RAS-driven cancers, but its role in therapeutic resistance is unknown. <h4>Methods</h4> We developed a panel of patient-derived pancreatic cancer cell lines resistant to the MEK inhibitor trametinib. We used immunofluorescenc...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: eaf63c8b-fe8c-5e43-88b7-5314ce4cf29a
DOI: 10.64898/2026.05.20.726663

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Reactivation of DRP1 plays a functional role in resistance to MEK inhibition in pancreatic cancer cellsDOI 10.64898/2026.05.20.726663Read

Inhibition of mitochondrial dynamics preferentially targets pancreatic cancer cells with enhanced tumorigenic and invasive potentialSemantic proximity Read

Mitochondrial Fusion Suppresses Pancreatic Cancer Growth via Reduced Oxidative MetabolismSemantic proximity Read

CDK5/CAMK2-DRP1-AMPK-Mediated Mitochondrial Fission is Required for Imatinib Resistance of CML CellsSemantic proximity Read

Vertical RAS-pathway inhibition in pancreatic cancer drives therapeutically exploitable mitochondrial alterationsSemantic proximity Read

Dynamin-Related Protein 1 at the Crossroads of CancerSemantic proximity Read

Mitochondrial Signatures Shape Phenotype Switching and Apoptosis in Response to PLK1 and RSK Inhibitors in MelanomaSemantic proximity Read

Tumor suppressor p53 restrains cancer cell dissemination by modulating mitochondrial dynamicsSemantic proximity Read

Tumor Suppressor p53 Restrains Cancer Cell Dissemination by Modulating Mitochondrial DynamicsSemantic proximity Read

PIM Kinases Alter Mitochondrial Dynamics and Chemosensitivity in Lung CancerSemantic proximity Read

Drp1-dependent remodeling of mitochondrial morphology triggered by EBV-LMP1 increases cisplatin resistanceSemantic proximity Read

Cell-specific models reveal conformation-specific RAF inhibitor combinations that synergistically inhibit ERK signaling in pancreatic cancer cellsSemantic proximity Read

<i>Drp1-JNK</i> knockdown mitigates Scribble loss induced cell proliferation, metastasis and lethality phenotypes in <i>Drosophila</i>Semantic proximity Read